Testosterone
New Insights for its Application in Men and Women
Uwe D Rohr
Universitätsfrauenklinik
Abt. für Gynäkologische Endokrinologie und Sterilitätsbehandlung
Medizinische Universität Wien - Österreich
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- Testosterone
- Production
In males produced by Leydig Cells
6-7 mg / day
In females by
- conversion of DHEA to T
- in ovaries
- 200-300 µg
- Name (68 Years old)
- „testo“ = testes
- „ster“ = sterol
- „one“ = ketone
- Testosterone
- Scientific research for 150 years
- 1927 isolation from bull testes (McGee)
- 1937 chemical synthesis by 3 groups
Butenandt rewarded Nobel Prize 1937
- 1969 DHT (Dehydrotestsoterone) discovered
- 2003 Nongenomic and Genomic Action of Androgen Receptor
- History of Testosterone in Therapy
- 1918 Vasectomy Therapy by Eugen Steinach (1861-1944) in Vienna
- 1927 First Definition of „Male Climacteric“ by A. Hoche in Germany
- 1946 Heller and Myers „controlled clinical trial“ T for male climacteric symptoms
- 1946 first description of male climacteric:
Nervousness, sweating, decreased potency
- Ernest Hemingway T replacement for ten years
Longest patient history
- Testosterone Metabolism
- Testosterone Increase Inhibiting Degredation with an Aromatase Inhibitor Anastrozol (Aromasin®)
- 2 types of androgenic Alopecia
- Morbus Addison (Bronzehautkrankheit)
- Störung der Nebennierenrinde
Niedriger Cortsionspiegel
- Fehlen von DHEA
- Auto-Immunerkrankungen
- Androgen-Mangel
- Psychosen
- Muskelschwund
- Bei DHEA – Gabe hohe Libido
- Wirksamkeit von Androstendione
- Estradiol und Testosteron
- Morbus Addison (Bronzehautkrankheit)
- Störung der Nebennierenrinde Niedriger Cortsionspiegel
- Fehlen von DHEA
Auto-Immunerkrankungen
- Androgen-Mangel
- Psychosen
- Muskelschwund
- Bei DHEA – Gabe hohe Libido
- Wirksamkeit von Androstendione
- Estradiol und Testosteron
- Testosterone and Male Age
Serum
- Cortisone and Male Age
- Testosterone as an Index of Male Hypogonadism
- Synonyms for Androgen Deficiency
- Andropause
- Male climacteric
- Aquired male hypogonadism
- Late onset hypogonadism
- Androgen decline in aging males (ADAM)
- Partial androgen decline in aging males - PADAM
- Improved Physical Strength in Men with Ischemic Heart Disease after Testosterone Therapy
- Testosterone reduces Myocardial Infarction
- Reduces Infarction Rate 25%
- Via a non-genomic Mechanism
Evidence of a direct Calcium Antagonism Action
- Improve Haemodynamic effects
- Reduces Severity of a Myocardial Infarction
- Testosterone Treatment and Physical Appearance
- Dose Dependent Effect of Testosterone on Regional Adipose Tissue
- Depression und Dementia
- Free testosterone and risk for Alzheimer disease in older men
- Testosterone vs Age in Women
- Testosterone improves muscle Contractability and Strength in Clitoris
- Potential Risk with Testosterone
- Potential Risk with Testosterone Replacement Therapy
- Prostate cancer and Testosterone
Prostate Cancer and Testosterone
- Hormone Replacement in Women
- Estrogen + Progesterone
protects Endometrium of Uterus
- Estrogen and Testosterone
- protect Breast Tissue?
- reduces Mitosis Rate
- Reduces Breast Endothel Tissue in Monkey
- Comparison of Injectable and transdermal Testosterone by a Patch
- Multiple Consecutively Application of Testosterone by a Gel
- No Interpersonal Testosterone Transfer after Topical Application
- Buccal Delivery of Testosterone
- Repeated Buccal Delivery of Testosterone
- Dose Dependent Pharmacokinetics of oral Testosterone Andriol Testocaps®
- Steady State Development of Testosterone and Route of Delivery
- Recommendations for Monitoring Testosterone-Replacement Therapy
- Clinical Indication to keep for Testosterone in normal age-related Values
- Men
- Reduce Cardiovascular Risk
- Maintain body weight
- Maintain “well being”
- Reduce Alzheimer Risk
- Women
- Reduce Cardiovascular Risk
- Reduce Breast Cancer Risk
- Keep body weight
- Maintain well being and libido
- Maintain bone health